Haploidentical transplantation: finally, some light
نویسندگان
چکیده
منابع مشابه
Haploidentical transplantation in children.
Tirado et al are puzzling in view of the elevated IgE levels in WAS patients,7 considering that IgE production is dependent on IL-4. If Th2 cells are deficient in IL-4 secretion, where does IL-4 come from? Morales-Tirado et al show that basophils and the minor T-cell subpopulation T cells can produce IL-4 in a manner independent of WASp. They propose that these cells are responsible for IL-4 pr...
متن کاملHaploidentical Hematopoietic Stem-Cell Transplantation in Adults
Haploidentical hematopoietic stem-cell transplantation is an alternative transplant strategy for patients without an HLA-matched donor. Still, only half of patients who might benefit from transplantation are able to find an HLA-matched related or unrelated donor. Haploidentical donor is readily available for many patients in need of immediate stem-cell transplantation. Historical experience wit...
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Hematopoietic stem cell transplantation from haploidentical donors is an attractive method of transplantation due to the immediate donor availability, ease of stem cell procurement and the possibility to collect additional donor cells for cellular therapy, if needed. Historically, maintaining T-cells in the graft has been associated with very high rates of graft-versus-host disease, while T-cel...
متن کاملT cell depleted haploidentical transplantation: positive selection
Interest in mismatched transplantation arises from the fact that a suitable one-haplotype mismatched donor is immediately available for virtually all patients, particularly for those who urgently need an allogenic transplant. Work on one haplotype-mismatched transplants has been proceeding for over 20 years all over the world and novel transplant techniques have been developed. Some centres hav...
متن کاملHaploidentical transplantation of hematopoietic stem cells.
OBJECTIVE To review and discuss the literature on hematopoietic stem cell transplantation (HSCT) with haploidentical donors in Brazil. METHOD Literature review. RESULTS The haploidentical hematopoietic stem cell transplantations have become a safe option in hematology since the 80s, with the possibility of ex-vivo T-cell depletion. However, its broad use worldwide occurred with the advent o...
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ژورنال
عنوان ژورنال: Blood
سال: 2021
ISSN: ['1528-0020', '0006-4971']
DOI: https://doi.org/10.1182/blood.2020008767